Articles and publication on how important microcirculation is.
To find articles and publications on the importance of microcirculation, you can refer to the following sources:
- The paper “Microcirculation: Physiology, Pathophysiology, and Clinical Application” reviews the physiological components of the microcirculation, emphasizing its role in homeostasis, oxygen transport to tissue cells, and circulatory compromise in shock and renal conditions – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7114900/
- An article discusses the significance of microcirculation in clinical practice, highlighting how patients with chronic angina are at increased risk of adverse cardiovascular events due to microcirculatory dysfunction – https://academic.oup.com/eurheartjsupp/article/21/Supplement_B/B25/5422922
- Another source emphasizes the importance of standardized microcirculatory monitoring for critically ill patients, suggesting that assessing the microcirculation at the bedside could guide therapies and improve outcomes in various clinical conditions, including sepsis – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3471451/
- A review article underscores the need to transform microcirculation monitoring into an essential bedside technique to optimize organ perfusion and oxygenation, stressing that current hemodynamic resuscitation methods do not adequately reflect tissue perfusion – https://ccforum.biomedcentral.com/articles/10.1186/s13054-023-04474-x
- An article from AHA Journals discusses how the human microcirculation plays a crucial role in adjusting vascular tone to match local tissue perfusion with oxygen demand, highlighting its significance in maintaining tissue health and function – https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.115.305364
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These sources provide valuable insights into the importance of microcirculation in various clinical contexts and underscore its critical role in maintaining tissue viability and supporting organ function.
The Human Microcirculation
David D. Gutterman, Dawid S. Chabowski, Andrew O. Kadlec, Matthew J. Durand, Julie K. Freed, Karima Ait-Aissa and Andreas M. Beyer
Originally published8 Jan 2016 – https://doi.org/10.1161/CIRCRESAHA.115.305364 Circulation Research. 2016;118:157–172
This study explores the role of microcirculation in predicting and understanding cardiovascular events and conduit artery disease. It reveals that microvascular dysfunction often precedes and predicts the development of artery atherosclerosis and its risk factors. Even in cases with minimal coronary artery disease, impaired vasodilation is observed.
The study suggests that microvascular function serves as an early indicator of cardiovascular disease, sometimes even before angiographic evidence of atherosclerosis. Notably, women with angina syndromes and normal conduit arteries exhibit a higher degree of microvascular disease.
The dysfunction in microcirculation is associated with various diseases beyond cardiovascular conditions, including obstructive sleep apnea, hypertrophic cardiomyopathy, and systemic lupus erythematosus. Genetic associations have also been identified, shedding light on potential therapeutic targets. While invasive methods are traditionally used to assess microcirculation, recent advancements in noninvasive techniques offer promising alternatives.
Direct assessment of microvascular function in vitro using human tissue samples provides valuable insights into disease mechanisms and potential treatments. Overall, the study underscores the significance of understanding microcirculation in predicting and managing cardiovascular events and diseases.
Read the full study: https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.115.305364
